Neurobiology of Disease Cell-Mediated Neuroprotection in a Mouse Model of Human Tauopathy
نویسندگان
چکیده
David W. Hampton,1,3* Daniel J. Webber,1,2,3* Bilada Bilican,1,2,3 Michel Goedert,4 Maria Grazia Spillantini,3 and Siddharthan Chandran1,2,3 1Euan MacDonald Centre for Motor Neurone Disease Research, Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom, 2Anne McLaren Laboratory for Regenerative Medicine, Medical Research Council Centre for Stem Cell Biology and Regenerative Medicine, University of Cambridge, Cambridge CB2 0SZ, United Kingdom, 3Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 2PY, United Kingdom, and 4Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
منابع مشابه
Cell-mediated neuroprotection in a mouse model of human tauopathy.
Tau protein in a hyperphosphorylated state makes up the intracellular inclusions of several neurodegenerative diseases, including Alzheimer's disease and cases of frontotemporal dementia. Mutations in Tau cause familial forms of frontotemporal dementia, establishing that dysfunction of tau protein is sufficient to cause neurodegeneration and dementia. Transgenic mice expressing human mutant tau...
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